An acquired disease is not contagious or inherited from a family member. It's a disease you develop over time.
An overreaction after a substance is introduced into the body.
A condition in which your body does not have enough hemoglobin (the part of your blood that carries oxygen). With anemia, you may have fewer whole red blood cells. This may cause you to feel weak and tired.
Aplastic anemia (AA)
"Aplastic" means that bone marrow can't produce new blood cells properly. As a result, patients with aplastic anemia have fewer red blood cells, white blood cells, and platelets. PNH is often found along with aplastic anemia.
atypical Hemolytic Uremic Syndrome (aHUS)
A disease of the blood that causes low red blood cell and platelet counts, kidney failure, and damage to other vital organs, such as the heart and brain.
Blood clots form when parts of your body's blood clump together. In a healthy body, this can stop bleeding when you're cut or injured. But in certain conditions, these clumps can block blood flow in the veins and arteries, which can be dangerous. In PNH, a clot can happen at any time and can cause serious health problems.
The soft tissue inside your large bones. It works to create the cells in your blood: red blood cells, white blood cells, and platelets.
Bone marrow failure disorder
A disorder that causes bone marrow to decrease or stop making blood cells. AA and MDS are bone marrow failure disorders.
The percentage of blood cells in your body affected by PNH.
Components in the blood that interact as part of the bodys immune system to destroy disease-causing substances.
Complete blood count (CBC)
A lab test that gives the amounts of different cells in your blood.
A treatment for kidney failure. Normally, the kidneys work to filter the blood and remove waste, excess salt, and water. Kidney failure, also called “end-stage renal disease,” occurs when the kidneys stop working completely. During hemodialysis, a machine takes over the job of the kidneys by filtering the blood outside of the body and then returning the filtered blood back to the body.
A type of protein that helps reactions/processes happen in the body.
Erectile dysfunction (ED)
A condition found in men that affects their ability to achieve an erection.
Food and Drug Administration.
Relating to genes, which are units in cells that are passed down through families.
The reddish-brown material found inside red blood cells. It carries oxygen throughout your body. When it gets outside of your cells, it is harmful and can lead to serious health problems.
Hemoglobin in the urine. About 25% of patients with PNH have it at diagnosis, but most will experience it at some time. Because of the reddish-brown color of hemoglobin, it results in dark, sometimes "cola-colored" urine.
When red blood cells burst. Hemolysis is the main cause of the major health problems in PNH.
A complex group of cells, proteins, and other molecules that work together to identify foreign organisms and substances, such as bacteria; the main role of the system is to protect the body against these foreign organisms.
An immune system reaction from the body as a result of some type of injury. Signs of inflammation may be redness, swelling, pain, and/or heat.
A process during which fluid is introduced into the body through a vein.
Lactate dehydrogenase (LDH)
An enzyme found in red blood cells, released during hemolysis. Testing for LDH can help show how much hemolysis is happening in your body.
An infection caused by a group of bacteria called Neisseria meninigitidis. The most common forms of meningococcal infections include meningitis (infection of the membranes that surround the brain and spinal cord) and meningococcernia (blood stream infections).
Myelodysplastic syndromes (MDS)
A condition in which there's a problem with the way bone marrow makes blood cells. About 2% of PNH patients also have MDS.
The body's natural protective immune system that regulates the body's immune response.
Paroxysmal nocturnal hemoglobinuria (PNH)
A disease where red blood cells are created without proteins. This causes red blood cells to burst (a process called hemolysis) and can result in serious health problems. Signs and symptoms include stomach pain, difficulty swallowing, anemia, shortness of breath, and tiredness. Life-threatening complications from PNH include blood clots, kidney failure, and damage to organs.
The pale yellow liquid part of whole blood, in which the red and white blood cells and various other elements are floating.
Plasma exchange/plasma infusion (PE/PI)
A process of removing, treating, and returning, or infusing plasma to the body.
A small, irregular, disc-shaped element in the blood that assists in blood clotting.
A progressive disease is one that gets worse over time.
High blood pressure in the arteries that deliver blood to the lungs. This means that blood has a hard time getting to the lungs, causing your heart to pump harder.
Red blood cells (RBCs)
A type of cell found in your blood that delivers oxygen and removes waste (carbon dioxide) in your body. Red blood cells affected by PNH are attacked and destroyed because they are missing a protective protein.
A transfusion is a painless procedure in which a person is given blood or other vital fluids directly into the vein.
Thrombotic microangiopathy (TMA)
Formation of clots in small blood vessels throughout the body; this is an underlying cause of the clinical signs and symptoms of aHUS.
A preparation that is used to increase the body's natural defense against a disease.
White blood cells (WBCs)
A type of cell found in your blood that helps your immune system fight disease and infection.